“an astroglial potassium channel (Kir4.1) is upregulated in the LHb in rat models of depression”

Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression | Nature

“The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has attracted enormous interest in mental health research owing to its rapid antidepressant actions, but its mechanism of action has remained elusive. Here we show that blockade of NMDAR-dependent bursting activity in the ‘anti-reward center’, the lateral habenula (LHb), mediates the rapid antidepressant actions of ketamine in rat and mouse models of depression.”

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression | Nature

“Here’s the trick: English is just lots of words (are you with me so far?) – we can also think of it as lots of pairs of words and lots of triples of words. Thus the first sentence of the above paragraph has the triples: “Wouldn’t you like” “you like to” and “like to write””

“I Spent an Interesting Evening Recently with a Grain of Salt”

“complexities are necessary for advanced cognition that seem to evade current Deep Learning systems. These include robustness to adversarial features, learning to forget, learning what to ignore, learning abstraction and recognizing contextual switching.”

Surprise! Neurons are Now More Complex than We Thought!!

“designs for board games that investigate the impact technologies might have on industries —transportation, healthcare and housing as they meet Augmented Reality, blockchain and big data.”

Simon Denny: The Founder’s Paradox | MOCA Cleveland