“Furthermore, it is generally accepted that within 15–20 years after surgery, aseptic loosening of the implants is almost inevitable. If infection is excluded, the most frequent complication associated with joint replacement is the deterioration of the prosthetic components and the resulting biological response of the body to the material released by the implant.”

The effects on bone cells of metal ions released from orthopaedic implants. A review
https://jhavelikes.tumblr.com/post/186282112100

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