“Microglia are the resident immune cells of the brain. Their physiological role is to protect the brain from infection and damage, to promote tissue repair and regeneration, and to nurture neurons and other glial cells by secretion of growth factors, cytokines and other signal molecules. Microglia are also involved in the removal of synapses in the framework of neuronal plasticity in the healthy brain. Some of the microglial processes rest for several minutes and make direct contact with neuronal synapses at a frequency of about one per hour. Neuronal activity regulates the microglial engulfment of synaptic structures, whereas microglial cells preferentially remove less active inputs.”

Marcus Semtner | Max Delbrück Center for Molecular Medicine

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