🧬 Personal DNA Analysis Report

Automated genomic analysis performed on January 23, 2026
Analysis time: ~12 minutes from raw data to comprehensive report
Learn how this analysis was performed →

Generated by Claude (Cowork) from a single text file in one automated session

⚠️ Important Medical Disclaimer

This analysis is for informational and educational purposes only. It is NOT medical advice and should NOT be used for diagnostic or treatment decisions. Genetic risk factors are complex and influenced by many genes, environmental factors, and lifestyle choices. Please consult with a healthcare provider or genetic counselor for professional interpretation of your genetic data.

664,421

Total SNPs

Analyzed Markers

High Risk

Moderate Risk

Protective

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APOE Genotype Analysis

APOE ε3/ε3

Average risk (most common genotype)

The ε3/ε3 genotype is the most common APOE variant, found in approximately 60% of the population. This genotype is associated with average Alzheimer's disease risk—neither increased nor decreased compared to the general population. The APOE gene provides instructions for making apolipoprotein E, which is involved in cholesterol transport and brain health.

SNP Details: rs7412: C/C | rs429358: T/T

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Health & Disease Risk Markers

⚠️ High Risk Markers (2 copies)

Type 2 Diabetes Risk

HIGH RISK

Gene: PPARG (rs1801282)

C/C

You carry two copies of the C allele, which means you lack the protective Pro12Ala (G) variant. The G allele provides modest protection against type 2 diabetes. Having C/C is common and represents typical risk, but lifestyle factors (diet, exercise, weight management) remain crucial for diabetes prevention.

Type 2 Diabetes Risk

HIGH RISK

Gene: CDKN2A/B (rs10811661)

T/T

You carry two copies of the T (risk) allele at this locus on chromosome 9, which is associated with increased type 2 diabetes risk. This region is near genes involved in cell cycle regulation and has been consistently linked to diabetes in genome-wide studies. Combined with other diabetes risk variants, this suggests diabetes screening and prevention strategies may be particularly important.

Blood Pressure & Cardiovascular Health

VARIANT

Gene: ACE (rs4994)

A/A

This marker relates to the ACE insertion/deletion polymorphism. The A/A genotype is associated with higher ACE enzyme levels, which may affect blood pressure regulation and cardiovascular health. Interestingly, this same variant has been associated with sprint performance in athletes. Regular blood pressure monitoring may be beneficial.

⚡ Moderate Risk Markers (1 copy)

Coronary Artery Disease

MODERATE

Gene: CDKN2A/B (rs1333049)

G/C

You carry one copy of the C (risk) allele, which is associated with increased risk of coronary artery disease and myocardial infarction (heart attack). This is one of the most robust genetic associations with cardiovascular disease. Lifestyle factors such as diet, exercise, smoking cessation, and cholesterol management are especially important.

Asthma Medication Response

PHARMACOGENETIC

Gene: ADRB2 (rs1042713)

A/G

You carry one copy of the G allele at the Arg16Gly variant of the beta-2 adrenergic receptor. This may influence response to beta-agonist asthma medications (albuterol, etc.). If you have asthma, your healthcare provider can use this information to optimize treatment selection.

Type 2 Diabetes Risk

MODERATE

Gene: IGF2BP2 (rs4402960)

T/G

You carry one T (risk) allele. This gene is involved in insulin secretion and glucose metabolism. This is another diabetes risk variant adding to your overall genetic risk profile.

Type 2 Diabetes Risk

MODERATE

Gene: SLC30A8 (rs13266634)

T/C

You carry one T (risk) allele. This gene encodes a zinc transporter in pancreatic beta cells. The risk allele is associated with reduced insulin secretion.

Vitamin B12 & Folate Metabolism

MODERATE

Gene: MTRR (rs1801394)

A/G

You carry one copy of the G variant, which may affect methionine synthase reductase enzyme function. This enzyme is involved in vitamin B12 and folate metabolism, which are important for homocysteine regulation. Adequate B12 and folate intake is recommended.

✓ Protective Markers

Alzheimer's Disease Protection

PROTECTIVE

Gene: APOE (rs7412 & rs429358)

ε3/ε3

Your APOE ε3/ε3 genotype represents average Alzheimer's risk. You do not carry the high-risk ε4 allele (which would significantly increase risk) nor the protective ε2 allele. This is the most common genotype worldwide and is considered the "neutral" reference.

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Trait & Characteristic Markers

Lactose Intolerance

LIKELY

Gene: LCT (rs4988235)

A/A

You carry two copies of the A allele, which is associated with lactase non-persistence (lactose intolerance in adulthood). The G allele, common in European populations, confers the ability to digest lactose throughout life. Most of the world's population loses lactase activity after childhood. If you experience digestive discomfort with dairy, this genetic variant provides a clear explanation.

Pain Sensitivity & Stress Response

MIXED

Gene: COMT (rs4680)

A/G

You are heterozygous (A/G) at the "Worrier/Warrior" gene. The A allele (Met variant) is associated with slower dopamine breakdown, leading to higher pain sensitivity but better memory and cognitive performance under normal conditions. The G allele (Val variant) is associated with faster dopamine breakdown, lower pain sensitivity, and better performance under stress. Your mixed genotype gives you an intermediate phenotype.

Empathy & Social Behavior

MIXED

Gene: OXTR (rs53576)

A/G

You carry one copy of the G allele and one A allele. The G allele of the oxytocin receptor gene is associated with increased empathy, social skills, and optimism. The A allele is associated with lower empathy and higher stress reactivity. Your heterozygous status suggests intermediate social-emotional traits.

Muscle Fiber Composition

TYPICAL

Gene: ACTN3 (rs1815739)

C/C

You carry two C alleles, meaning you produce functional alpha-actinin-3 protein in fast-twitch muscle fibers. This variant is associated with better sprint and power performance. The T allele (which you don't have) results in absence of this protein and is associated with better endurance performance.

Bitter Taste Perception

MIXED TASTER

Gene: TAS2R38 (rs713598)

C/G

You are heterozygous at this bitter taste receptor variant. The G allele is associated with the ability to taste bitter compounds like PTC and PROP (supertaster), while C is associated with reduced bitter taste sensitivity. You likely have intermediate bitter taste perception.

Circadian Rhythm / Chronotype

INTERMEDIATE

Gene: CLOCK (rs1726866)

A/G

You carry a heterozygous genotype at this circadian rhythm gene variant. The G allele has been associated with evening preference (being a "night owl"). Your mixed genotype suggests an intermediate chronotype, neither strongly morning nor evening oriented.

Pigmentation Traits

VARIOUS

Genes: MC1R, OCA2, SLC24A4, TYR

Multiple markers

Your genetic profile shows various pigmentation-related variants. You carry one T allele at MC1R rs1805008 (associated with red hair/fair skin tendencies), typical variants at other MC1R sites, and pigmentation-influencing variants at OCA2, SLC24A4, and TYR genes. These collectively influence hair, skin, and eye color. You carry two T alleles at OCA2 rs1800404 and two G alleles at SLC24A4 rs12896399, both influencing pigmentation traits.

Dopamine Function

INTERMEDIATE

Gene: ANKK1/DRD2 (rs1800497)

A/G

You carry one copy of each allele at the Taq1A polymorphism. The T allele (A1) is associated with reduced dopamine D2 receptor density and has been linked to addiction susceptibility, reward-seeking behavior, and obesity risk. Your heterozygous status suggests intermediate dopamine receptor density.

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Ancestry & Geographic Origins

Genetic Ancestry Signals

European Ancestry 3 markers

Primary ancestry signal

Based on key ancestry-informative SNPs, your genetic profile shows strong European ancestry signals. This is determined by variants that differ in frequency across continental populations.

Key Ancestry-Informative Markers

European Light Skin Pigmentation

ANCESTRY

Gene: SLC24A5 (rs1426654)

A/A

You carry two copies of the A allele, which is nearly fixed (98%+) in European populations and rare in African and East Asian populations. This variant is the single largest contributor to light skin pigmentation and is one of the strongest ancestry markers. The derived A allele arose approximately 18,000-30,000 years ago.

European Ancestry / Light Pigmentation

ANCESTRY

Gene: SLC45A2 (rs16891982)

G/G

You carry two copies of the G allele, which is common in European populations (95%+) and contributes to light skin pigmentation. This is another strong European ancestry marker.

Blue Eye Color (European)

ANCESTRY

Gene: HERC2 (rs12913832)

G/G

You carry two copies of the G allele, which is strongly associated with blue eyes. This variant is highly predictive of eye color and is most common in Northern European populations. The blue eye allele is thought to have originated around 6,000-10,000 years ago near the Black Sea region. This is a strong European ancestry marker.

East Asian Marker

ANCESTRY

Gene: EDAR (rs3827760)

A/A

You carry two copies of the ancestral A allele. The derived T allele (370A variant) is nearly fixed in East Asian populations (93%+) and is associated with thicker hair shafts, specific tooth shape (shovel-shaped incisors), and increased sweat gland density. Your A/A genotype is typical of non-East Asian ancestry.

East Asian Skin Pigmentation Marker

ANCESTRY

Gene: OCA2 (rs1800414)

T/T

You carry two copies of the ancestral T allele. The A allele is found primarily in East Asian populations and contributes to lighter skin pigmentation in those populations. Your T/T genotype is consistent with non-East Asian ancestry.

📊 Ancestry Summary

Your genetic profile strongly indicates European ancestry, based on multiple ancestry-informative markers including near-homozygous European-specific alleles for light skin pigmentation (SLC24A5, SLC45A2), blue eye color (HERC2), and absence of East Asian-specific variants (EDAR, OCA2). The lactose intolerance genotype (LCT A/A) indicates a non-Northern European ancestral background, as lactase persistence is most common in Northern Europe, particularly Scandinavia and the British Isles. This genetic signature suggests likely Southern or Eastern European, Mediterranean, or mixed European ancestry.

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Key Health Insights Summary

Notable Findings

🔴 Higher Genetic Risk Areas:

Type 2 Diabetes: Multiple risk variants (PPARG, CDKN2A/B, IGF2BP2, SLC30A8) suggest increased genetic susceptibility. Prevention through diet, exercise, weight management, and regular screening is particularly important.
Cardiovascular Health: Risk variants in CDKN2A/B (coronary artery disease) and ACE (blood pressure regulation) warrant attention to heart-healthy lifestyle factors and blood pressure monitoring.

🟢 Favorable Findings:

Alzheimer's Disease: APOE ε3/ε3 genotype represents average (neutral) risk—no elevated risk from the ε4 variant.
Athletic Potential: ACTN3 C/C genotype associated with fast-twitch muscle fibers and sprint/power performance capability.

🔵 Actionable Information:

Lactose Intolerance: A/A genotype strongly predicts lactose intolerance in adulthood. Consider dairy alternatives or lactase supplements.
Vitamin Metabolism: MTRR variant may affect B12/folate metabolism. Ensure adequate intake through diet or supplementation.
Medication Response: ADRB2 variant may influence asthma medication effectiveness—discuss with healthcare provider if relevant.

Remember: Genes are not destiny. Lifestyle factors (diet, exercise, sleep, stress management, avoiding smoking) often have equal or greater impact on health outcomes than genetic variants. Use this information as a tool for informed health decisions in consultation with healthcare professionals.

⚠️ High Risk (2 risk alleles)

⚡ Moderate Risk (1 risk allele)

✓ Protective

• Neutral / Typical